HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2371927Generated: November 1, 2026
Ethylenediamine → 6-[4-[2-aminoethylcarbamoylmethoxy]phenyl]-4,5-dihydro3(2H)-pyridazinone
https://huagongshe.com/reaction/2371927
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethylenediamine | HCID 3301 | — |
| Reactant | 6-(4-carbethoxymethoxyphenyl)-4,5-dihydro-3(2H)-pyridazinone | HCID 13687676 | — |
| Product | 6-[4-[2-aminoethylcarbamoylmethoxy]phenyl]-4,5-dihydro3(2H)-pyridazinone | HCID 15016342 | 80.3% |
Reaction Steps
A mixture of 2.85 g (10.3 mmol) of 6-(4-carboethoxymethoxyphenyl)-4,5-dihydro-3(2H)-pyridazinone (prepared as described in Example 13) and 9.3 g (155 mmol) of ethylenediamine is heated at 60° C. under N2 for 30 min. Volatile materials are removed in vacuo, and the residue is recrystallized from methanol-EtOAc to give 2.40 g of 6-[4-[2-aminoethylcarbamoylmethoxy]phenyl]-4,5-dihydro-3(2H)-pyridazinone as a white solid, m.p. 176°-177.5° C. Yield, 80%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05096904 |
|---|
| Source dataset | uspto-grants-1992_03 |
|---|
| ORD ID | ord-42b62b2821c147f1ba967f0843e4c8cd |
|---|
| Source note | uspto-grants-1992_03 |
|---|
