Ammonia → HCID 15614241, compound
Reaction equation
F[C:2]1[C:7]([F:8])=[C:6]([F:9])[CH:5]=[C:4]([F:10])[C:3]=1[C:11]([F:14])([F:13])[F:12].[NH3:15]>O1CCCC1>[F:8][C:7]1[C:6]([F:9])=[CH:5][C:4]([F:10])=[C:3]([C:11]([F:14])([F:13])[F:12])[C:2]=1[NH2:15]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
110 g of 2,3,4,6-tetrafluorobenzotrifluoride in 200 ml of tetrahydrofuran are initially introduced into a stainless steel autoclave of capacity 0.7 1, and 30 ml of liquid ammonia are injected. The batch is then heated at 100° C. for 3 hours (maximum pressure: 10 bar). After cooling, the pressure is released and the liquid phase is subjected to fractional distillation. First, at a boiling point of 47° C.-48° C./8 mbar, 42 g of 2,3,5-trifluoro-6-trifluoromethylaniline are obtained, and then, following an intermediate fraction and at a boiling point of 75° C.-78° C./ 8 mbar, 46 g of 2,3,5-trifluoro-4-trifluoromethylaniline.
Workup
- temperatureAfter cooling
- distillationthe liquid phase is subjected to fractional distillation
Sources & evidence
- ORD record
- ord-902aae438099422f9790d74bb409e337
- Source dataset
- uspto-grants-1992_03
- Patent number
- US05096928
Reaction notes
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