Ammonia → 4-Amino-2,3-difluorobenzotrifluoride
Reaction equation
[F:1][C:2]1[C:7]([F:8])=[C:6](F)[CH:5]=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11].[NH3:14]>O1CCCC1>[F:8][C:7]1[C:2]([F:1])=[C:3]([C:10]([F:13])([F:12])[F:11])[CH:4]=[CH:5][C:6]=1[NH2:14]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 130 °C
Procedure
200 g of 2,3,4-trifluoro-benzotrifluoride in 500 ml of tetrahydrofuran are initially introduced into an autoclave, and 60 ml of liquid ammonia are injected. The batch is stirred at 130° C. (maximum pressure 18 bar) for 6 hours and then cooled and the pressure is released. At a boiling point of 92° -93° C./26 mbar, 92 g of 2,3-di- fluoro-4-trifluoromethylaniline are obtained by distillation.
Workup
- temperaturecooled
Sources & evidence
- ORD record
- ord-18bab3b999c74ef3a990361afb37ff7c
- Source dataset
- uspto-grants-1992_03
- Patent number
- US05096928
Reaction notes
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