HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2371953Generated: October 25, 2026
Ammonia → 4-Amino-2,3-difluorobenzotrifluoride
https://huagongshe.com/reaction/2371953
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1,2,3-Trifluoro-4-(trifluoromethyl)benzene | HCID 2734025 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Amino-2,3-difluorobenzotrifluoride | HCID 2735902 | — |
Reaction Steps
200 g of 2,3,4-trifluoro-benzotrifluoride in 500 ml of tetrahydrofuran are initially introduced into an autoclave, and 60 ml of liquid ammonia are injected. The batch is stirred at 130° C. (maximum pressure 18 bar) for 6 hours and then cooled and the pressure is released. At a boiling point of 92° -93° C./26 mbar, 92 g of 2,3-di- fluoro-4-trifluoromethylaniline are obtained by distillation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05096928 |
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| Source dataset | uspto-grants-1992_03 |
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| ORD ID | ord-18bab3b999c74ef3a990361afb37ff7c |
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| Source note | uspto-grants-1992_03 |
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