HCID 19905482, compound → HCID 19905492, compound

HRID 2371966Notes

Reaction equation

HRID 2371966 reaction equation
[CH3:1][NH:2][C:3]([N:5]([CH:14]([C:16]1[CH:21]=[CH:20][C:19]([N:22]2[C:26]([CH3:27])=[CH:25][CH:24]=[C:23]2[CH3:28])=[CH:18][CH:17]=1)[CH3:15])[O:6]CC1C=CC=CC=1)=[O:4]>C(OCC)(=O)C>[CH3:1][NH:2][C:3]([N:5]([CH:14]([C:16]1[CH:21]=[CH:20][C:19]([N:22]2[C:26]([CH3:27])=[CH:25][CH:24]=[C:23]2[CH3:28])=[CH:18][CH:17]=1)[CH3:15])[OH:6])=[O:4]

Participants

3

Reactant 1

HCID 19905482HCID 19905482, compound

Product 1

HCID 19905492HCID 19905492, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of 0.7 g of N-(N'-methylcarbamoyl)-N-benzyloxy-1-[4-(2,5-dimethyl-1H-pyrrol-1-yl)-phenyl]-ethyl-amine in 50 ml of ethyl acetate is hydrogenated at room temperature and 3 atmospheres pressure for 3 hours to yield N-(N'-methylcarbamoyl)-N-hydroxy-1-[4-(2,5-dimethyl-1H-pyrrol-1-yl)-phenyl]-ethylamine; m.p. 131°-133°.

Workup

  1. customis hydrogenated at room temperature

Sources & evidence

ORD record
ord-e23bfc9136c44514ad4599939f56b543
Source dataset
uspto-grants-1992_03
Patent number
US05096919

Reaction notes

Loading…