反应详情

Triethylamine (2.06 g) is added to a mixture of 5.0 g of (E)-3-[4-(2,5-dimethyl-1H-pyrrol-1-yl)-phenyl]-N-hydroxy-N-methyl-2-propenamide in 100 ml of methylene chloride and the mixture is stirred for 15 minutes. Acetic anhydride (2.07 g) is added and the mixture is stirred at room temperature overnight. The reaction mixture is washed with water and sodium bicarbonate solution, the organic layer is separated, treated with charcoal, dried and evaporated to dryness. The residue is crystallized from ethanol, water (1:1) to yield (E)-3-[4-(2,5-dimethyl-1H-pyrrol-1-yl)-phenyl]-N-acetoxy-N-methyl-2-propenamide, m.p. 120°-121°.

1. stirringthe mixture is stirred at room temperature overnight
2. washThe reaction mixture is washed with water and sodium bicarbonate solution
3. customthe organic layer is separated
4. additiontreated with charcoal
5. customdried
6. customevaporated to dryness
7. customThe residue is crystallized from ethanol, water (1:1)