Dimethylformamide → HCID 22803977, compound

HRID 2372012Notes

Reaction equation

HRID 2372012 reaction equation
[OH:1][CH2:2][C@@H:3]1[CH:18]=[C:17]2[C@@H:7]([CH2:8][C:9]3[C:19]4[C:12](=[CH:13][CH:14]=[CH:15][C:16]2=4)[NH:11][CH:10]=3)[N:5]([CH3:6])[CH2:4]1.CN(C)C=O>[Pd].N1C=CC=CC=1>[OH:1][CH2:2][C@@H:3]1[CH:18]=[C:17]2[C@@H:7]([CH2:8][CH:9]3[C:19]4[C:12](=[CH:13][CH:14]=[CH:15][C:16]2=4)[NH:11][CH2:10]3)[N:5]([CH3:6])[CH2:4]1

Participants

5

Reactant 2

HCID 6228DimethylformamideHCID 149871413-67-8

Product 1

HCID 22803977HCID 22803977, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 1049PyridineSolvent

Procedure

catalytically hydrogenating under a pressure of 1 to 5 bar, a reaction mixture comprising lysergol and least one aprotic solvent containing a tertiary nitrogen a solvent mixture of N,N-dimethylformamide and pyridine and a 5 to 10% palladium catalyst applied on activated carbon, at a temperature between 40° C. and the boiling point of the reaction mixture, to form dihydrolysergol; and

Workup

  1. customapplied on activated carbon, at a temperature between 40° C.

Sources & evidence

ORD record
ord-ad66960c942e470b87e1f50a3f3616dd
Source dataset
uspto-grants-1992_03
Patent number
US05097031

Reaction notes

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