Thionyl Chloride → 2,2-Difluoro-1-methylcyclopropane-1-carbonyl chloride

HRID 2372038Notes

Reaction equation

HRID 2372038 reaction equation
[F:1][C:2]1([F:9])[CH2:4][C:3]1([CH3:8])[C:5](O)=[O:6].S(Cl)([Cl:12])=O>>[F:1][C:2]1([F:9])[CH2:4][C:3]1([CH3:8])[C:5]([Cl:12])=[O:6]

Participants

3

Reactant 2

HCID 24386Thionyl Chloride2×HCID 146952292,2-Difluoro-1-methylcyclopropane-1-carboxylic acid

Product 1

HCID 146952322,2-Difluoro-1-methylcyclopropane-1-carbonyl chlorideYield 77%

Procedure

A mixture of 250 g (1.8 mol) of 2,2-difluoro-1-methyl-cyclopropanecarboxylic acid and 700 ml of thionyl chloride is slowly heated in a distillation apparatus, during which process excess thionyl chloride distils over first and the desired product later. In this manner, 215 g (77% of theory) of 2,2-difluoro-1-methylcyclopropanecarbonyl chloride are obtained in form of a liquid of boiling point 121°-122° C. ##STR55##

Workup

  1. customdistils over first and the desired product later

Sources & evidence

ORD record
ord-397f97d6646c465cb09a5c3147268777
Source dataset
uspto-grants-1992_03
Patent number
US05097050

Reaction notes

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