HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2,2-Difluoro-1-methylcyclopropane-1-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2,2-Difluoro-1-methylcyclopropane-1-carboxylic acid | HCID 14695229 | — |
| Product | 2,2-Difluoro-1-methylcyclopropane-1-carbonyl chloride | HCID 14695232 | 77% |
Reaction Steps
A mixture of 250 g (1.8 mol) of 2,2-difluoro-1-methyl-cyclopropanecarboxylic acid and 700 ml of thionyl chloride is slowly heated in a distillation apparatus, during which process excess thionyl chloride distils over first and the desired product later. In this manner, 215 g (77% of theory) of 2,2-difluoro-1-methylcyclopropanecarbonyl chloride are obtained in form of a liquid of boiling point 121°-122° C. ##STR55##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05097050 |
| Source dataset | uspto-grants-1992_03 |
| ORD ID | ord-397f97d6646c465cb09a5c3147268777 |
| Source note | uspto-grants-1992_03 |