Hydrogen Bromide → HCID 14098533, compound

HRID 2372086Notes

Reaction equation

HRID 2372086 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[C:9]([O:17]C)[C:10]([F:16])=[C:11]([F:15])[C:12]=3[F:14])[C:7](=[O:19])[C:6]([C:20]([OH:22])=[O:21])=[CH:5]2)[CH2:3][CH2:2]1.Br>C(O)(=O)C>[CH:1]1([N:4]2[C:13]3[C:8](=[C:9]([OH:17])[C:10]([F:16])=[C:11]([F:15])[C:12]=3[F:14])[C:7](=[O:19])[C:6]([C:20]([OH:22])=[O:21])=[CH:5]2)[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 15052644HCID 15052644, compound

Product 1

HCID 14098533HCID 14098533, compoundYield 80.3%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To 1.5 g of 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-5-methoxy-4-oxo-3-quinolinecarboxylic acid was added 25 ml of hydrogen bromide in acetic acid (32%). The mixture was stirred at room temperature for 16 hours and concentrated to dryness. The residue was triturated with water:ethanol and filtered to give 1.15 g of the title compound.

Workup

  1. concentrationconcentrated to dryness
  2. customThe residue was triturated with water
  3. filtrationethanol and filtered

Sources & evidence

ORD record
ord-9739de83fbfd427988c0cafb4629028e
Source dataset
uspto-grants-1992_03
Patent number
US05097032

Reaction notes

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