Hydrochloric Acid → HCID 14896566, compound

HRID 2372088Notes

Reaction equation

HRID 2372088 reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[C:8]([NH2:28])[C:9]([F:27])=[C:10]([N:14]3[CH2:18][CH2:17][CH:16]([NH:19]C(OC(C)(C)C)=O)[CH2:15]3)[C:11]=2[F:13])[C:6](=[O:29])[C:5]([C:30]([OH:32])=[O:31])=[CH:4]1)[CH3:2].[ClH:33]>C(O)(=O)C>[ClH:33].[CH2:1]([N:3]1[C:12]2[C:7](=[C:8]([NH2:28])[C:9]([F:27])=[C:10]([N:14]3[CH2:18][CH2:17][CH:16]([NH2:19])[CH2:15]3)[C:11]=2[F:13])[C:6](=[O:29])[C:5]([C:30]([OH:32])=[O:31])=[CH:4]1)[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19905730HCID 19905730, compound

Product 1

HCID 14896566HCID 14896566, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A near solution of 4.5 g (10 mmole) of 1-ethyl-5-amino-6,8-difluoro-7-[3-(t-butoxycarbonylamino)-1-pyrrolidinyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, 10 ml of 6.0M hydrochloric acid and 100 ml of glacial acetic acid is heated at 60° C. for four hours and then stirred at room temperature for 18 hours. The solvent is removed in vacuo, the residue triturated with ethanol/ether (1:1), filtered, washed with ether, and dried in vacuo to give the title compound.

Workup

  1. customThe solvent is removed in vacuo
  2. customthe residue triturated with ethanol/ether (1:1)
  3. filtrationfiltered
  4. washwashed with ether
  5. customdried in vacuo

Sources & evidence

ORD record
ord-9d9cc7b7846048f78b92ab7065f8e951
Source dataset
uspto-grants-1992_03
Patent number
US05097032

Reaction notes

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