反应详情

A solution of 2-[methyl(trityl)amino]-1-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazol-5-yl)ethanol (0.7 g, 1.36 mmol) in 20 mL of MeOH was treated with a solution of 4N HCl in dioxane (20 mL) and refluxed overnight. After cooling to room temperature, the solvent was removed by evaporation in vacuum and the residue was suspended in EtOAc. The solid was collected by filtration and washed with hot EtOAc. A white solid 0.23 g was obtained after drying under vacuum.

1. temperaturerefluxed overnight
2. customthe solvent was removed by evaporation in vacuum
3. filtrationThe solid was collected by filtration
4. washwashed with hot EtOAc