Hydrochloric Acid → HCID 22574356, compound

HRID 23721Notes

Reaction equation

HRID 23721 reaction equation
[CH3:1][N:2](C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[CH2:3][CH:4]([C:6]1[N:10](COCC[Si](C)(C)C)[N:9]=[CH:8][CH:7]=1)[OH:5].[ClH:38]>CO.O1CCOCC1>[ClH:38].[ClH:38].[CH3:1][NH:2][CH2:3][CH:4]([C:6]1[NH:10][N:9]=[CH:8][CH:7]=1)[OH:5]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 225744142-(methyl(trityl)amino)-1-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-5-yl)ethanol

Product 1

HCID 22574356HCID 22574356, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 2-[methyl(trityl)amino]-1-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazol-5-yl)ethanol (0.7 g, 1.36 mmol) in 20 mL of MeOH was treated with a solution of 4N HCl in dioxane (20 mL) and refluxed overnight. After cooling to room temperature, the solvent was removed by evaporation in vacuum and the residue was suspended in EtOAc. The solid was collected by filtration and washed with hot EtOAc. A white solid 0.23 g was obtained after drying under vacuum.

Workup

  1. temperaturerefluxed overnight
  2. customthe solvent was removed by evaporation in vacuum
  3. filtrationThe solid was collected by filtration
  4. washwashed with hot EtOAc

Sources & evidence

ORD record
ord-7f360c7e75904149999e828a7a8ce523
Source dataset
uspto-grants-2005_02
Patent number
US06852731B2

Reaction notes

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