Hydride → HCID 54032019, compound

Participants

Reaction Steps

Next, a hydride of boron or aluminum or palladium catalyst is allowed to act on 5-benzyloxy-1,1,1-trifluoro-3-pentyne-2-ol (compound (3)) to obtain 5-benzyloxy-1,1,1-trifluoro-3-pentene-2-ol (E)-(5) or (Z)-(5). This is acetylated or isobutylated and then thereon is allowed lipases or lipases-producing microorganism to act to obtain optically active (R)-5-benzyloxy-1,1,1-trifluoro-3-pentene-2-ol [(R)-(E)-5] or [(R)-(Z)-5] and optically active (S)-2-acetoxy (or butoxy)-5-benzyloxy-1,1,1-trifluoro-3-pentene [(S)-(E)-6 or (S)-(Z)-6].

Provenance & Evidence