Sodium Azide → 1-Azido-1-deoxy-4-O-methanesulfonyl-2,3,5-tri-O-benzyl-L-xylitol

HRID 2372148Notes

Reaction equation

[N-:1]=[N+:2]=[N-:3].[Na+].CS(O[CH2:10][C@H:11]([C@@H:20]([C@H:29]([CH2:35][O:36][CH2:37][C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)[O:30][S:31]([CH3:34])(=[O:33])=[O:32])[O:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)(=O)=O>CN(C)C=O>[N:1]([CH2:10][C@H:11]([C@@H:20]([C@H:29]([CH2:35][O:36][CH2:37][C:38]1[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=1)[O:30][S:31]([CH3:34])(=[O:33])=[O:32])[O:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[O:12][CH2:13][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)=[N+:2]=[N-:3]

Participants

Conditions

Temperature: 60 °C

Procedure

A mixture of sodium azide (1.72 g, 26.4 mmol) and 1,4-di-O-methanesulfonyl-2,3,5-tri-O-benzyl-L-xylitol (13.9 g, 24 mmol) in dimethylformamide (500 mL) is heated overnight at 60° C. under stirring. Dimethylformamide is evaporated under reduced pressure. The residue is dissolved in ethyl acetate and washed with water. The organic layer is dried over sodium sulfate, filtered and concentrated under reduced pressure, yielding an oil. Flash chromatography on silica gel and elution with a 7:3 mixture of cyclohexane and ethyl acetate yield 1-azido-1-deoxy-4-O-methanesulfonyl -2,3,5-tri-O-benzyl-L-xylitol (8.6 g, 63%) as an oil.

Workup

customDimethylformamide is evaporated under reduced pressure
dissolutionThe residue is dissolved in ethyl acetate
washwashed with water
dry with materialThe organic layer is dried over sodium sulfate
filtrationfiltered
concentrationconcentrated under reduced pressure
customyielding an oil
washFlash chromatography on silica gel and elution
additionwith a 7:3 mixture of cyclohexane and ethyl acetate

Sources & evidence

ORD record: ord-075598ebd05e4193a185cc2842501696
Source dataset: uspto-grants-1992_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05097023

Reaction notes

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