反应详情

A solution of 1,4-di-O-acetyl-2,3,6-tri-O-benzyl-D-galactopyranose (4.64 g, 8.67 mmol) in ether (10 mL) was treated with ethereal hydrogen chloride (0.2 g/mL, 25 mL). The mixture was stirred at room temperature during 48 h. The solvents were evaporated under reduced pressure to afford an oil. Flash chromatography on silica gel and elution with a graded mixture of carbon tetrachloride and ethyl acetate afforded 4-O-acetyl-2,3,6-tri-O-benzyl-α-D-galactopyranosyl chloride (3.142 g, 71%) as an oil.

1. customThe solvents were evaporated under reduced pressure
2. customto afford an oil
3. washFlash chromatography on silica gel and elution
4. additionwith a graded mixture of carbon tetrachloride and ethyl acetate