HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(1H-imidazol-2-yl)-2-(methylamino)ethanol dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-(methyl(trityl)amino)-1-(1-trityl-1H-imidazol-2-yl)ethanol | HCID 22574314 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-(1H-imidazol-2-yl)-2-(methylamino)ethanol dihydrochloride | HCID 22574357 | — |
Reaction Steps
A solution of 2-[methyl(trityl)amino]-1-(1-trityl-1H-imidazol-2-yl)ethanol (3.4 g, 5.43 mmol) in 70 mL of acetone was treated with a solution of 4N HCl in dioxane (5 mL) and stirred for 4 h at room temperature. The solvent was removed by evaporation in vacuum and the residue was suspended in EtOAc. The solid was collected by filtration and washed with hot EtOAc. A white solid, 0.92 g (79%) was obtained after drying under vacuum. mp 176.4-177.3° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06852731B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-df2cb512d2644b57bf388cf5c89fc2cc |
| Source note | uspto-grants-2005_02 |