Hydrochloric Acid → 1-(1H-imidazol-2-yl)-2-(methylamino)ethanol dihydrochloride

HRID 23722Notes

Reaction equation

HRID 23722 reaction equation
[CH3:1][N:2](C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[CH2:3][CH:4]([C:6]1[N:7](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:8]=[CH:9][N:10]=1)[OH:5].[ClH:49]>CC(C)=O.O1CCOCC1>[ClH:49].[ClH:49].[NH:7]1[CH:8]=[CH:9][N:10]=[C:6]1[CH:4]([OH:5])[CH2:3][NH:2][CH3:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 225743142-(methyl(trityl)amino)-1-(1-trityl-1H-imidazol-2-yl)ethanol

Product 1

HCID 225743571-(1H-imidazol-2-yl)-2-(methylamino)ethanol dihydrochloride

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 2-[methyl(trityl)amino]-1-(1-trityl-1H-imidazol-2-yl)ethanol (3.4 g, 5.43 mmol) in 70 mL of acetone was treated with a solution of 4N HCl in dioxane (5 mL) and stirred for 4 h at room temperature. The solvent was removed by evaporation in vacuum and the residue was suspended in EtOAc. The solid was collected by filtration and washed with hot EtOAc. A white solid, 0.92 g (79%) was obtained after drying under vacuum. mp 176.4-177.3° C.

Workup

  1. customThe solvent was removed by evaporation in vacuum
  2. filtrationThe solid was collected by filtration
  3. washwashed with hot EtOAc
  4. customA white solid, 0.92 g (79%) was obtained
  5. customafter drying under vacuum

Sources & evidence

ORD record
ord-df2cb512d2644b57bf388cf5c89fc2cc
Source dataset
uspto-grants-2005_02
Patent number
US06852731B2

Reaction notes

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