反应详情

A solution of 2-[methyl(trityl)amino]-1-(1-trityl-1H-imidazol-2-yl)ethanol (3.4 g, 5.43 mmol) in 70 mL of acetone was treated with a solution of 4N HCl in dioxane (5 mL) and stirred for 4 h at room temperature. The solvent was removed by evaporation in vacuum and the residue was suspended in EtOAc. The solid was collected by filtration and washed with hot EtOAc. A white solid, 0.92 g (79%) was obtained after drying under vacuum. mp 176.4-177.3° C.

1. customThe solvent was removed by evaporation in vacuum
2. filtrationThe solid was collected by filtration
3. washwashed with hot EtOAc
4. customA white solid, 0.92 g (79%) was obtained
5. customafter drying under vacuum