反应详情

A solution of 3-fluorophenyl isocyanate (5.0 g, 36.0 mmol) in 20 ml of toluene is added to hydrazine hydrate (2.1 g, 42.0 mmol) in 70 ml of dioxane, maintaining the temperature of the reaction at less than 12°. After 2 hours, the reaction is filtered and the solvent is removed from the filtrate by rotoevaporation to give the white solid, 4-(3-fluorophenyl)-semicarbazide.

1. temperaturemaintaining
2. customthe temperature of the reaction at less than 12°
3. filtrationthe reaction is filtered
4. customthe solvent is removed from the filtrate by rotoevaporation