Hydrazine hydrate (1:1) → 4-(3-FLUOROPHENYL)SEMICARBAZIDE

HRID 2372207Notes

Reaction equation

HRID 2372207 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N:8]=[C:9]=[O:10])[CH:5]=[CH:6][CH:7]=1.O.[NH2:12][NH2:13]>C1(C)C=CC=CC=1.O1CCOCC1>[F:1][C:2]1[CH:3]=[C:4]([NH:8][C:9](=[O:10])[NH:12][NH2:13])[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 1230643-Fluorophenyl isocyanate

Product 1

HCID 75679044-(3-FLUOROPHENYL)SEMICARBAZIDE

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 3-fluorophenyl isocyanate (5.0 g, 36.0 mmol) in 20 ml of toluene is added to hydrazine hydrate (2.1 g, 42.0 mmol) in 70 ml of dioxane, maintaining the temperature of the reaction at less than 12°. After 2 hours, the reaction is filtered and the solvent is removed from the filtrate by rotoevaporation to give the white solid, 4-(3-fluorophenyl)-semicarbazide.

Workup

  1. temperaturemaintaining
  2. customthe temperature of the reaction at less than 12°
  3. filtrationthe reaction is filtered
  4. customthe solvent is removed from the filtrate by rotoevaporation

Sources & evidence

ORD record
ord-950999e15d684a439a758878ce4d3ae9
Source dataset
uspto-grants-1992_03
Patent number
US05098466

Reaction notes

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