反应详情

A mixture of ethyl N-(2-fluorophenyl)carbamate (8.3 g, 45.4 mmol) and hydrazine hydrate (13.6 g, ca. 14 ml) in 40 ml of absolute ethanol is heated to reflux. After 3 days, the reaction mixture is concentrated, and the solid is filtered, washed with water and with ether and dried to give 4-(2-fluoro-phenyl)semicarbazide.

1. temperatureis heated to reflux
2. concentrationthe reaction mixture is concentrated
3. filtrationthe solid is filtered
4. washwashed with water and with ether
5. customdried