Hydrazine hydrate (1:1) → HCID 3271329, compound

HRID 2372209Notes

Reaction equation

HRID 2372209 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:13])OCC.O.[NH2:15][NH2:16]>C(O)C>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:13])[NH:15][NH2:16]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 242730ethyl N-(2-fluorophenyl)carbamate

Product 1

HCID 3271329HCID 3271329, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of ethyl N-(2-fluorophenyl)carbamate (8.3 g, 45.4 mmol) and hydrazine hydrate (13.6 g, ca. 14 ml) in 40 ml of absolute ethanol is heated to reflux. After 3 days, the reaction mixture is concentrated, and the solid is filtered, washed with water and with ether and dried to give 4-(2-fluoro-phenyl)semicarbazide.

Workup

  1. temperatureis heated to reflux
  2. concentrationthe reaction mixture is concentrated
  3. filtrationthe solid is filtered
  4. washwashed with water and with ether
  5. customdried

Sources & evidence

ORD record
ord-445c690ba92141099f83f2efc403049a
Source dataset
uspto-grants-1992_03
Patent number
US05098466

Reaction notes

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