HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azobisisobutyronitrile → Ethyl 4-chloro-2-(1-bromoethyl)nicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azobisisobutyronitrile | HCID 6547 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Ethyl 4-chloro-2-ethylpyridine-3-carboxylate | HCID 19902853 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | Ethyl 4-chloro-2-(1-bromoethyl)nicotinate | HCID 19902854 | — |
Reaction Steps
A mixture of the above ethylnicotinate (5.45 g), N-bromosuccinimide (NBS) (5.50 g) and 2,2'-azobis(2-methylpropionitrile) (AIBN) (0.40 g) in carbon tetrachloride (50 ml) is heated under reflux for 2 hours, then cooled, filtered and concentrated in vacuo to give ethyl 4-chloro-2-(1-bromoethyl)-nicotinate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05098466 |
| Source dataset | uspto-grants-1992_03 |
| ORD ID | ord-d8cd7413f6154ee082ebce9472397793 |
| Source note | uspto-grants-1992_03 |