反应详情

A mixture of the above ethylnicotinate (5.45 g), N-bromosuccinimide (NBS) (5.50 g) and 2,2'-azobis(2-methylpropionitrile) (AIBN) (0.40 g) in carbon tetrachloride (50 ml) is heated under reflux for 2 hours, then cooled, filtered and concentrated in vacuo to give ethyl 4-chloro-2-(1-bromoethyl)-nicotinate.

1. temperatureis heated
2. temperatureunder reflux for 2 hours
3. temperaturecooled
4. filtrationfiltered
5. concentrationconcentrated in vacuo