反应详情

To 75 ml of an aqueous solution of 13% potassium hydroxide were added 120 ml of ethanol and 10 g (43.1 mmol) of the above 3'-fluoro-4'-hydroxybiphenyl-4-carboxylic acid, which were refluxed for 30 minutes and added with 25.0 g (129 mmol) of 1-bromooctane and then refluxed for 15 hours. After the air cooling, the precipitated crystal was filtered and recrystallized with acetic acid containing 5% hydrochloric acid and further with acetic acid to obtain 12.8 g (yield: 86.4%) of 3'-fluoro-4'-octyloxybiphenyl-4-carboxylic acid. This compound had the following properties:

1. temperaturewere refluxed for 30 minutes
2. temperaturerefluxed for 15 hours
3. temperatureAfter the air cooling
4. filtrationthe precipitated crystal was filtered
5. customrecrystallized with acetic acid containing 5% hydrochloric acid and further with acetic acid