反应详情

A mixture of 0.75 g of 2,4-dihydroxy-5-ethyl-acetophenone, 1.23 g of ethyl 2-acetoxy-4-bromomethylbenzoate, 0.57 g of potassium carbonate, and a catalytic amount of potassium iodide were heated at reflux in methyl ethyl ketone overnight. The hot mixture was filtered and the filtrate concentrated to dryness. Crystallization of the residue from ethyl acetate/hexane provided 130 mg of the desired title product, m.p. 145°-146° C.

1. filtrationThe hot mixture was filtered
2. concentrationthe filtrate concentrated to dryness
3. customCrystallization of the residue from ethyl acetate/hexane