Hydroxyamine hydrochloride → HCID 86745563, compound

HRID 2372279Notes

Reaction equation

HRID 2372279 reaction equation
[C:1]([C:4]1[C:21]([OH:22])=[CH:20][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([CH3:19])([CH3:18])[C:15]([OH:17])=[O:16])=[C:6]([CH2:23][CH3:24])[CH:5]=1)(=O)[CH3:2].Cl.[NH2:26][OH:27].C([O-])(=O)C.[Na+]>CO>[OH:27][N:26]=[CH:2][CH2:1][C:4]1[C:21]([OH:22])=[CH:20][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([CH3:19])([CH3:18])[C:15]([OH:17])=[O:16])=[C:6]([CH2:23][CH3:24])[CH:5]=1

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 14820108HCID 14820108, compound

Product 1

HCID 86745563HCID 86745563, compoundYield 42.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 7.1 g of 7-(4-acetyl-2-ethyl-5-hydroxyphenoxy)-2,2-dimethylheptanoic acid, 0.149 g of hydroxylamine hydrochloride, 0.176 g of sodium acetate, and 50 ml of methanol were heated at reflux for 48 hours. The reaction mixture was allowed to cool to room temperature and the resulting solid collected by filtration. The solid was crystallized from methylene chloride/hexane to provide 0.32 g of the desired titled product.

Workup

  1. temperaturewere heated
  2. temperatureat reflux for 48 hours
  3. filtrationthe resulting solid collected by filtration
  4. customThe solid was crystallized from methylene chloride/hexane

Sources & evidence

ORD record
ord-ee8a7deb2e7d4625812e6b0cd17230fb
Source dataset
uspto-grants-1992_03
Patent number
US05098613

Reaction notes

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