反应详情

3-O-Benzylglycerol (9.0 g, 0.05 mole) and 25 g (0.08 mole) of 1-bromohexadecane are dissolved in 50 ml of dry benzene, 8.8 g (0.16 mole) of potassium hydroxide is added to the solution, and the mixture is heated under reflux with stirring for 16 hours. The reaction mixture is neutralized by adding hydrochloric acid then extracted with 50 ml of ethyl acetate. The extract is washed in sequence with 2.5% potassium hydrogen carbonate and water and dried over anhydrous sodium sulfate. The solvent is then distilled off under reduced pressure to give 35 g of an oily residue.

1. temperaturethe mixture is heated
2. temperatureunder reflux
3. extractionthen extracted with 50 ml of ethyl acetate
4. washThe extract is washed in sequence with 2.5% potassium hydrogen carbonate and water
5. dry with materialdried over anhydrous sodium sulfate
6. distillationThe solvent is then distilled off under reduced pressure