HCID 19903224, compound → 1-[[1-[5-Hydroxy-2-(trifluoromethyl)-4-pyrimidinyl]-4-piperidinyl]methyl]-2-pyrrolidinone

HRID 2372323Notes

Reaction equation

HRID 2372323 reaction equation
C1(C[O:8][C:9]2[C:10]([N:19]3[CH2:24][CH2:23][CH:22]([CH2:25][N:26]4[CH2:30][CH2:29][CH2:28][C:27]4=[O:31])[CH2:21][CH2:20]3)=[N:11][C:12]([C:15]([F:18])([F:17])[F:16])=[N:13][CH:14]=2)C=CC=CC=1>C(O)C.[Pd]>[OH:8][C:9]1[C:10]([N:19]2[CH2:24][CH2:23][CH:22]([CH2:25][N:26]3[CH2:30][CH2:29][CH2:28][C:27]3=[O:31])[CH2:21][CH2:20]2)=[N:11][C:12]([C:15]([F:17])([F:16])[F:18])=[N:13][CH:14]=1

Participants

4

Reactant 1

HCID 19903224HCID 19903224, compound

Product 1

HCID 199032161-[[1-[5-Hydroxy-2-(trifluoromethyl)-4-pyrimidinyl]-4-piperidinyl]methyl]-2-pyrrolidinoneYield 55.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of XXVI (0.90 g, 2.1 mmol) in ethanol (75 mL) was hydrogenated with 10% Pd/C (0.20 g) at 60 psi for 2 hr. The mixture was filtered and concentrated in vacuo to give the product as a white powder (0.40 g, 54%, mp: 213°-215°).

Workup

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-844e12f213264890b8a5246fad4bbc10
Source dataset
uspto-grants-1992_03
Patent number
US05098904

Reaction notes

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