Diethyl Sulfate → HCID 13853879, compound

HRID 2372340Notes

Reaction equation

[Cl:1][C:2]1[C:3](=[O:23])[N:4]([C:19]([CH3:22])([CH3:21])[CH3:20])[N:5]=[CH:6][C:7]=1[NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]([OH:18])=[O:17])=[CH:12][CH:11]=1.S(OCC)(O[CH2:28]C)(=O)=O>>[Cl:1][C:2]1[C:3](=[O:23])[N:4]([C:19]([CH3:20])([CH3:22])[CH3:21])[N:5]=[CH:6][C:7]=1[NH:8][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]([O:18][CH3:28])=[O:17])=[CH:14][CH:15]=1

Participants

Reactant 2

HCID 6163Diethyl Sulfate

HCID 13853865HCID 13853865, compound

Product 1

HCID 13853879HCID 13853879, compound

Procedure

The compounds as identified in Table 12 were prepared in the synthetic manner and after-treatment similar to those in Example 5 except that the carboxylic acids with Y1, Y2, Y3, R1, R2 and R3 as identified in Table 12 were used instead of the starting 4-chloro-5-(4-carboxybenzylamino)-2-t-butyl-3(2H)pyridazinone used in Example 5. For the preparation of Compound No. 52, diethyl sulfate was used as an esterifying agent. In the NMR data, only the characteristic absorptions are given in Table 12.

Workup

customwere prepared in the synthetic manner
customFor the preparation of Compound No

Sources & evidence

ORD record: ord-0e0dc27573624cb581aba73b8e62de39
Source dataset: uspto-grants-1992_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05098900

Reaction notes

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