Ethanol → HCID 13853900, compound

HRID 2372350Notes

Reaction equation

HRID 2372350 reaction equation
Cl[C:2]1[C:3](=[O:23])[N:4]([CH:20]([CH3:22])[CH3:21])[N:5]=[CH:6][C:7]=1[NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][C:11]=1[O:18][CH3:19].C(O)C.[H][H]>[C].[Pd].C(N(CC)CC)C>[CH3:19][O:18][C:11]1[CH:12]=[C:13]([O:16][CH3:17])[CH:14]=[CH:15][C:10]=1[CH2:9][NH:8][C:7]1[CH:6]=[N:5][N:4]([CH:20]([CH3:22])[CH3:21])[C:3](=[O:23])[CH:2]=1

Participants

6

Reactant 3

HCID 702EthanolHCID 13853923HCID 13853923, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 13853900HCID 13853900, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8471TriethylamineSolvent

Procedure

320 mg of 4-chloro-5-(2,4-dimethoxybenzylamino)-2-i-propyl-3(2H)pyridazinone (Compound No. 97), 50 ml of ethanol, 1 ml of triethylamine and 100 mg of palladium-carbon were stirred, and hydrogen was added to the mixture at a temperature of from 40° to 50° C. for 3 hours. The reaction mixture was filtered, and the filtrate was evaporated. The crude crystals thereby obtained were recrystallized from ethyl ether to obtain 230 mg of the above identified compound having a melting point of from 167 to 168° C.

Workup

  1. filtrationThe reaction mixture was filtered
  2. customthe filtrate was evaporated
  3. customThe crude crystals thereby obtained
  4. customwere recrystallized from ethyl ether
  5. customto obtain 230 mg of the
  6. customof from 167 to 168° C.

Sources & evidence

ORD record
ord-a53d1f9fcc2f41ce87467a78cbcaa25d
Source dataset
uspto-grants-1992_03
Patent number
US05098900

Reaction notes

Loading…