Aluminium lithium hydride → 107259-16-5

HRID 2372355Notes

Reaction equation

HRID 2372355 reaction equation
[CH2:1]([N:8]1[CH2:12][CH:11]([C:13](=[N:15]O)[CH3:14])[CH2:10][C:9]1=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[NH2:15][CH:13]([CH:11]1[CH2:10][CH2:9][N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:12]1)[CH3:14]

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 85126173HCID 85126173, compound

Product 1

HCID 19000545107259-16-5Yield 102.7%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

30 ml of anhydrous tetrahydrofuran (THF) was added to 650 mg of 1-benzyl-4-(1-hydroxyiminoethyl)-2-pyrrolidone and 500 mg of lithium aluminum hydride and the obtained mixture was refluxed for 20 h. After the decomposition of lithium aluminum hydride, the precipitate was filtered and washed thoroughly with THF. The wash solution was added to the filtrate. The solvent was distilled off under reduced pressure to obtain 587 mg of the desired compound in the form of a light yellow oil.

Workup

  1. temperaturethe obtained mixture was refluxed for 20 h
  2. filtrationAfter the decomposition of lithium aluminum hydride, the precipitate was filtered
  3. washwashed thoroughly with THF
  4. additionThe wash solution was added to the filtrate
  5. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-f3c0550f610847ffaa4b4803b3204c42
Source dataset
uspto-grants-1992_03
Patent number
US05098912

Reaction notes

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