Lawesson's reagent → HCID 19903356, compound

HRID 2372375Notes

Reaction equation

HRID 2372375 reaction equation
O=[C:2]1[CH:6]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:5][CH2:4][NH:3]1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:23])=CC=1>C1C=CC=CC=1>[S:23]=[C:2]1[CH:6]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:5][CH2:4][NH:3]1

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 19903357tert-Butyl 2-oxopyrrolidine-3-carboxylate

Product 1

HCID 19903356HCID 19903356, compoundYield 111.6%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

1.7 g of tert-butyl 2-oxopyrrolidine-3-carboxylate and 1.8 g of Lawesson's reagent were added to 20 ml of benzene and stirred at 50° to 60° C. for 1 hour. After filtering the insoluble matters the solvent was distilled off and the obtained residue was purified by silica gel chromatography to thereby give 1.0 g of the title compound.

Workup

  1. filtrationAfter filtering the insoluble matters the solvent
  2. distillationwas distilled off
  3. customthe obtained residue was purified by silica gel chromatography

Sources & evidence

ORD record
ord-a44e7cac82c54dd79cc417382191c5d1
Source dataset
uspto-grants-1992_03
Patent number
US05098919

Reaction notes

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