Methylamine → HCID 67755339, compound

HRID 2372378Notes

Reaction equation

HRID 2372378 reaction equation
[CH:1]([O:4][C:5]([C:7]1[CH:8]([CH3:21])[CH2:9][N:10]2[C:14](=[CH:15][C:16](OCC)=[O:17])[CH2:13][S:12][C:11]=12)=[O:6])([CH3:3])[CH3:2].[CH3:22][NH2:23]>>[CH3:22][NH:23][C:16](=[O:17])[CH:15]=[C:14]1[CH2:13][S:12][C:11]2=[C:7]([C:5]([O:4][CH:1]([CH3:3])[CH3:2])=[O:6])[CH:8]([CH3:21])[CH2:9][N:10]12

Participants

3

Reactant 2

HCID 6329MethylamineHCID 85114049HCID 85114049, compound

Product 1

HCID 67755339HCID 67755339, compound

Procedure

1.2 g of ethyl (7-isopropoxycarbonyl-6-methyl-2,3,5,6-tetrahydropyrrolo[2,1-b]thiazol-3-ylidene]acetate was suspended in 25 ml of a 40% aqueous solution of monomethylamine and stirred at room temperature for 24 hours. The precipitate was collected by filtration, washed with water and recrystallized from ethanol to thereby give 1.2 g of the title compound.

Workup

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with water
  3. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-5b654898f4b7433fb98f98be75142a41
Source dataset
uspto-grants-1992_03
Patent number
US05098919

Reaction notes

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