Methylamine → HCID 19903332, compound

HRID 2372384Notes

Reaction equation

HRID 2372384 reaction equation
[CH:1]([O:4][C:5]([C:7]1[CH:8]([CH3:20])[CH2:9][N:10]2[CH:14]([CH2:15][C:16](OC)=[O:17])[CH2:13][S:12][C:11]=12)=[O:6])([CH3:3])[CH3:2].[CH3:21][NH2:22]>>[CH3:21][NH:22][C:16](=[O:17])[CH2:15][CH:14]1[CH2:13][S:12][C:11]2=[C:7]([C:5]([O:4][CH:1]([CH3:3])[CH3:2])=[O:6])[CH:8]([CH3:20])[CH2:9][N:10]12

Participants

3

Reactant 2

HCID 6329MethylamineHCID 56974243HCID 56974243, compound

Product 1

HCID 19903332HCID 19903332, compound

Procedure

To 4.5 g of methyl (7-isopropoxycarbonyl-6-methyl-2,3,5,6- tetrahydropyrrolo[2,1-b]thiazol-3-yl-)acetate was added 100 ml of a 40% aqueous solution of monomethylamine. The mixture was stirred at room temperature for 20 hours. After distilling off the monomethylamine, the residue was extracted with chloroform. The chloroform layer was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. After distilling off the solvent, 4.1 g of the title compound was obtained in the form of a colorless oily product.

Workup

  1. distillationAfter distilling off the monomethylamine
  2. extractionthe residue was extracted with chloroform
  3. washThe chloroform layer was washed with a saturated aqueous solution of sodium chloride
  4. dry with materialdried over anhydrous sodium sulfate
  5. distillationAfter distilling off the solvent

Sources & evidence

ORD record
ord-d13f300964124462bf482cddf81a215c
Source dataset
uspto-grants-1992_03
Patent number
US05098919

Reaction notes

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