反应详情

温度

-73 °C

Trimethylsilyl-bis(methylthio)methane, 2.65 g, was dissolved in 15 ml of tetrahydrofuran and 7 ml of 1.6 mole hexane solution of n-butyl lithium was dropwise added to the solution in an argon flow under ice cooling. The mixture was stirred at the same temperature for 30 minutes. After cooling to -73° C., a solution of 2.26 g of 4-phenoxypropiophenone in 5 ml of tetrahydrofuran was dropwise added to the mixture. Then, the temperature was gradually elevated to room temperature followed by stirring for 16 hours. After saturated sodium chloride aqueous solution was added to the mixture, it was extracted with chloroform. After drying the chloroform phase over magnesium sulfate, the solvent was distilled off under reduced pressure and the residue was purified by silica gel column chromatography (chloroform : hexane =1 : 1) to give 3.04 g of the oily product.

1. customwas gradually elevated to room temperature
2. stirringby stirring for 16 hours
3. extractionwas extracted with chloroform
4. dry with materialAfter drying the chloroform phase over magnesium sulfate
5. distillationthe solvent was distilled off under reduced pressure
6. customthe residue was purified by silica gel column chromatography (chloroform : hexane =1 : 1)