Methyl iodide → HCID 67798788, compound

HRID 2372464Notes

Reaction equation

[OH:1][CH:2]1[C:7]([O:26][CH3:27])([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH2:15][C:16]3[CH:25]=[CH:24][C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[CH:17]=3)[CH:9]=2)[CH2:6][CH2:5][O:4][CH2:3]1.[CH3:28]I>>[CH3:28][O:1][CH:2]1[C:7]([O:26][CH3:27])([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH2:15][C:16]3[CH:25]=[CH:24][C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[CH:17]=3)[CH:9]=2)[CH2:6][CH2:5][O:4][CH2:3]1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 67798347HCID 67798347, compound

Product 1

HCID 67798788HCID 67798788, compoundYield 90%

Procedure

Using the procedure described in Example 1, (3RS,4SR)-3-hydroxy-4-methoxy-4-[3-(naphth-2-ylmethoxy)phenyl]tetrahydropyran [Example 7, Compound No. 3] was reacted with methyl iodide to give (3RS,4SR)-3,4-dimethoxy-4-[3-(naphth-2-ylmethoxy)phenyl]tetrahydropyran (90%), m.p. 131°-133° C.

Sources & evidence

ORD record: ord-694825ce56844d1594245ca32d644594
Source dataset: uspto-grants-1992_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05098930

Reaction notes

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