Hydrogen Bromide → HCID 13201335, compound

HRID 2372600Notes

Reaction equation

HRID 2372600 reaction equation
C([O:5][C:6](=[O:51])[CH2:7][N:8]([C:18](=[O:50])[C@H:19]([CH2:35][CH2:36][CH2:37][CH2:38][NH:39]C(OCC1C=CC=CC=1)=O)[NH:20][C@@H:21]([C:30]([O:32][CH2:33][CH3:34])=[O:31])[CH2:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10]1)(C)(C)C.[BrH:52].CCOCC>C(O)(=O)C>[BrH:52].[BrH:52].[CH2:33]([O:32][C:30]([C@H:21]([NH:20][C@H:19]([C:18]([N:8]([CH:9]1[CH2:10][C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:17]1)[CH2:7][C:6]([OH:51])=[O:5])=[O:50])[CH2:35][CH2:36][CH2:37][CH2:38][NH2:39])[CH2:22][CH2:23][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)=[O:31])[CH3:34]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 3283Diethyl EtherHCID 13132322HCID 13132322, compound

Product 1

HCID 13201335HCID 13201335, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

Nα -[1-(R)-Ethoxycarbonyl-3-phenylpropyl]-Nε -carbobenzoxy-L-lysyl-N-(indan-2-yl)glycine tert-butyl ester (1 g) is dissolved in 2 ml of acetic acid. To the solution, 8 ml of 25% hydrobromic acid solution in acetic acid is added, and the mixture is allowed to stand at room temperature for 30 minutes. On adding 200 ml of ether and 100 ml of petroleum forms. This is collected by filtration and recrystallized from a mixture of methanol and ethyl ether to give 0.8 g of Nα -[1-(R)-ethoxycarbonyl-3-phenylpropyl]L-lysyl-N-(indan-2-yl)glycine dihydrobromide melting at [α]D24 =-11.6° (c=1, methanol)

Workup

  1. filtrationThis is collected by filtration
  2. customrecrystallized from a mixture of methanol and ethyl ether

Sources & evidence

ORD record
ord-1cd40c2cdebd4b3b92ffcfb3ef8004e7
Source dataset
uspto-grants-1992_03
Patent number
US05098892

Reaction notes

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