Ethanol → 1-(Benzothiophen-2-yl)piperazine

HRID 2372613Notes

Reaction equation

HRID 2372613 reaction equation
Cl[C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[NH:11]1[CH2:16][CH2:15]N[CH2:13][CH2:12]1.[CH2:17](O)C>>[S:3]1[C:2]([N:6]2[CH2:15][CH2:16][NH:11][CH2:12][CH2:13]2)=[CH:17][C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]1=2

Participants

4

Reactant 3

HCID 702EthanolHCID 4837PiperazineHCID 119872-Chlorobenzothiazole

Product 1

HCID 190649741-(Benzothiophen-2-yl)piperazine

Procedure

2-Chlorobenzothiazole (5 g) is heated in ethanol (75 ml) with piperazine (3.05 g) for 20 h. The mixture is partitioned between methylene chloride/ether and aqueous sodium bicarbonate. The organic phase is separated, dried with sodium sulfate and concentrated to give the title compound.

Workup

  1. customThe mixture is partitioned between methylene chloride/ether and aqueous sodium bicarbonate
  2. customThe organic phase is separated
  3. dry with materialdried with sodium sulfate
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-ed96206c87d34ecc8dcccd71bc35edca
Source dataset
uspto-grants-1992_03
Patent number
US05099019

Reaction notes

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