反应详情

温度

0 °C

1-[2'-Chlorophenylthio]-2-phenyl-2-propene (1.56 g, 0.006 mole) is dissolved in methylene chloride (50 cc) and cooled to 0° C. 55% strength mCPBA (1.9 g, 0.006 mole) in solution in methylene chloride (15 cc) is added dropwise over 30 min. After 1 hour at 0° C. the solution is washed with saturated sodium bicarbonate (75 cc), brine (2×75 cc) and is dried over MgSO4. The crude (1.6 g) is chromatographed on silica to give 1-[2'-chlorophenylsulphinyl]-2-phenyl-2-propene (1.0 g, 60%) in the form of an oil. nD25 =1.6250.

1. washAfter 1 hour at 0° C. the solution is washed with saturated sodium bicarbonate (75 cc), brine (2×75 cc)
2. dry with materialis dried over MgSO4
3. customThe crude (1.6 g) is chromatographed on silica