1-Phenylazetidin-3-ol → 3-[5-Bromo-2-(3-fluoro-benzyloxy)-phenoxy]-1-phenyl-azetidine

HRID 237268Notes

Reaction equation

HRID 237268 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[CH:12]=2)=[C:6]([OH:8])[CH:7]=1.[C:18]1([N:24]2[CH2:27][CH:26](O)[CH2:25]2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[CH:12]=2)=[C:6]([CH:7]=1)[O:8][CH:26]1[CH2:27][N:24]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:25]1

Participants

3

Reactant 2

HCID 224365261-Phenylazetidin-3-olHCID 673481595-Bromo-2-(3-fluoro-benzyloxy)-phenol

Product 1

HCID 584051753-[5-Bromo-2-(3-fluoro-benzyloxy)-phenoxy]-1-phenyl-azetidine

Procedure

Prepared by the procedure of Example 163 using 5-bromo-2-(3-fluoro-benzyloxy)-phenol and 1-phenyl-azetidin-3-ol. MS (ESI): mass calcd. for C22H19BrFNO2, 427.1; m/z found, 428.2 [M+H]+. 1H NMR (CDCl3): 7.34-6.47 (m, 12H), 5.11-5.03 (m, 3H), 4.36-4.28 (m, 2H), 3.98-3.91 (m, 2H).

Sources & evidence

ORD record
ord-0957b28c513c47f9bfcffb88fe74ffac
Source dataset
uspto-grants-2014_02
Patent number
US08642583B2

Reaction notes

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