U 84935 → HCID 70059045, compound

HRID 2372716Notes

Reaction equation

HRID 2372716 reaction equation
[CH:1]1([C:4]2[O:8][N:7]=[C:6]([C:9]3[N:10]=[CH:11][N:12]4[C:21]5[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=5[C:15]5=[N:22][CH2:23][CH2:24][N:14]5[C:13]=34)[N:5]=2)[CH2:3][CH2:2]1.[C:25]([OH:34])(=[O:33])[C@@H:26]([C@H:28]([C:30]([OH:32])=[O:31])[OH:29])[OH:27]>ClCCl>[C:30]([C@@H:28]([C@H:26]([C:25]([OH:34])=[O:33])[OH:27])[OH:29])([OH:32])=[O:31].[CH:1]1([C:4]2[O:8][N:7]=[C:6]([C:9]3[N:10]=[CH:11][N:12]4[C:21]5[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=5[C:15]5=[N:22][CH2:23][CH2:24][N:14]5[C:13]=34)[N:5]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 131796U 84935HCID 444305L-Tartaric acid

Product 1

HCID 70059045HCID 70059045, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Equimolar amounts of 5-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-2,3-dihydrodiimidazo[1,5-a:1',2'-c]quinazoline (0.64 g) and L-tartaric acid (0.30 g) was stirred in dichloromethane (25 ml) until a clear solution was obtained. The solvent was removed by evaporation in vacuo and the residue was triturated with isopropyl alcohol. The crystalline precipitate was filtered off and recrystallized from ethanol yielding the title compound as pale crystals, m.p. 160°-163° C. (Compound 41).

Workup

  1. customwas obtained
  2. customThe solvent was removed by evaporation in vacuo
  3. customthe residue was triturated with isopropyl alcohol
  4. filtrationThe crystalline precipitate was filtered off
  5. customrecrystallized from ethanol yielding the title compound as pale crystals, m.p. 160°-163° C. (Compound 41)

Sources & evidence

ORD record
ord-3ff57096c9694f3d9418f2558d2626f8
Source dataset
uspto-grants-1992_03
Patent number
US05100895

Reaction notes

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