Ethanolamine → HCID 19902157, compound

HRID 2372719Notes

Reaction equation

HRID 2372719 reaction equation
[Br:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4](Cl)=[N:5][C:6]([Cl:12])=[N:7]2.C(N(CC)CC)C.[CH2:21]([CH2:23][NH2:24])[OH:22]>ClCCl>[Br:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4]([NH:24][CH2:23][CH2:21][OH:22])=[N:5][C:6]([Cl:12])=[N:7]2

Participants

5

Reactant 3

HCID 700EthanolamineHCID 8471TriethylamineHCID 199021485-Bromo-2,4-dichloroquinazoline

Product 1

HCID 19902157HCID 19902157, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred mixture of 5-bromo-2,4-dichloroquinazoline (2.3 g, 8.2 mmol) and triethylamine (1.5 ml, 11 mmol) in dichloromethane (100 ml) was added ethanolamine (0.64 ml, 11 mmol), and the mixture was stirred for 30 min. The solvent was evaporated and the residue treated with a mixture of water (30 ml) and ether (20 ml) giving the title compound as a crystalline precipitate which was collected by filtration and dried, m.p. 165°-67° C.

Workup

  1. customThe solvent was evaporated
  2. additionthe residue treated with a mixture of water (30 ml) and ether (20 ml)

Sources & evidence

ORD record
ord-c31b0020aac84bdaaee3faa812158d57
Source dataset
uspto-grants-1992_03
Patent number
US05100895

Reaction notes

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