Hydrochloric Acid → HCID 19773546, compound

HRID 2372735Notes

Reaction equation

HRID 2372735 reaction equation
[OH:1][CH2:2][CH2:3][CH:4]1[CH2:10][CH:9]2[N:11](C(OCC)=O)[CH:6]([CH2:7][CH2:8]2)[CH2:5]1.Cl>>[CH:9]12[NH:11][CH:6]([CH2:7][CH2:8]1)[CH2:5][CH:4]([CH2:3][CH2:2][OH:1])[CH2:10]2

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 19748293HCID 19748293, compound

Product 1

HCID 19773546HCID 19773546, compoundYield 99.6%

Procedure

A mixture of 7.5 parts of ethyl 3-(2-hydroxyethyl)-8-azabicyclo[3.2.1]octane-8-carboxylate (prepared as in EP-A-0,320,032) and 127 parts of hydrochloric acid was refluxed for 1/2 hour and was then evaporated. The residue was taken up in water and the whole was basified with NaOH. The product was extracted with trichloromethane and the extract was washed, dried, filtered and evaporated, yielding 5.1 parts (99.6%) of 8-azabicyclo[3.2.1]octane-3-ethanol (interm. 40).

Workup

  1. temperaturewas refluxed for 1/2 hour
  2. customwas then evaporated
  3. extractionThe product was extracted with trichloromethane
  4. washthe extract was washed
  5. customdried
  6. filtrationfiltered
  7. customevaporated

Sources & evidence

ORD record
ord-eea3117db4994a729fefc61a2a38b024
Source dataset
uspto-grants-1992_03
Patent number
US05100893

Reaction notes

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