4-Piperidinecarboxylic acid → 1-Acetylpiperidine-4-carboxylic acid

HRID 2372739Notes

Reaction equation

HRID 2372739 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]([OH:9])=[O:8])[CH2:3][CH2:2]1.[C:10](OC(=O)C)(=[O:12])[CH3:11]>>[C:10]([N:1]1[CH2:6][CH2:5][CH:4]([C:7]([OH:9])=[O:8])[CH2:3][CH2:2]1)(=[O:12])[CH3:11]

Participants

3

Reactant 2

HCID 37734-Piperidinecarboxylic acidHCID 7918Acetic Anhydride

Product 1

HCID 1172551-Acetylpiperidine-4-carboxylic acidYield 79%

Procedure

100 g of 4-piperidinecarboxylic acid and 400 ml of acetic anhydride are mixed. The mixture is brought to reflux for 2 hours and then left overnight at room temperature. The reaction medium is concentrated and the residue is ground with ethyl ether, filtered off and then washed with ethyl ether to obtain the expected compound.

Workup

  1. temperatureto reflux for 2 hours
  2. concentrationThe reaction medium is concentrated
  3. filtrationfiltered off
  4. washwashed with ethyl ether

Sources & evidence

ORD record
ord-230d6e1cdadc44d2a10a6a5f42108d9a
Source dataset
uspto-grants-1992_03
Patent number
US05100902

Reaction notes

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