1-Acetyl-4-(2',4'-difluorobenzoyl)piperidine → (2,4-Difluorophenyl)(piperidin-4-yl)methanone

HRID 2372740Notes

Reaction equation

HRID 2372740 reaction equation
C([N:4]1[CH2:9][CH2:8][CH:7]([C:10](=[O:19])[C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:12]=2[F:18])[CH2:6][CH2:5]1)(=O)C>Cl>[F:18][C:12]1[CH:13]=[C:14]([F:17])[CH:15]=[CH:16][C:11]=1[C:10]([CH:7]1[CH2:6][CH2:5][NH:4][CH2:9][CH2:8]1)=[O:19]

Participants

3

Reactant 1

HCID 27407071-Acetyl-4-(2',4'-difluorobenzoyl)piperidine

Product 1

HCID 13076388(2,4-Difluorophenyl)(piperidin-4-yl)methanoneYield 83%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

30 g of 1-acetyl-4-(2,4-difluorobenzoyl)piperidine are brought to reflux in 113 ml of 6N hydrochloric acid for 6 hours. The reaction medium is then concentrated and the residue obtained is crystallized in isopropanol. The expected compound is isolated after filtration.

Workup

  1. concentrationThe reaction medium is then concentrated
  2. customthe residue obtained
  3. customis crystallized in isopropanol

Sources & evidence

ORD record
ord-5a5424fd76de439ea27c974720c1127d
Source dataset
uspto-grants-1992_03
Patent number
US05100902

Reaction notes

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