反应详情

0.0019 mole of 4-(2,4-difluorobenzoyl)piperidine, 0.0019 mole of benzocyclobuten-1-ylmethyl para-toluenesulfonate and 0.04 mole of triethylamine dissolved in 50 ml of toluene are mixed and then brought to reflux for 18 hours. The reaction medium is then extracted with 1N hydrochloric acid and the aqueous phase is alkalinized and extracted with dichloromethane. The oil obtained is purified on a silica column using a mixture of cyclohexane and acetone (93:7 V/V) as eluent.

1. additionare mixed
2. temperatureto reflux for 18 hours
3. extractionThe reaction medium is then extracted with 1N hydrochloric acid
4. extractionextracted with dichloromethane
5. customThe oil obtained
6. customis purified on a silica column
7. additiona mixture of cyclohexane and acetone (93:7 V/V) as eluent