Aniline → 2-Anilinonicotinic acid

HRID 2372755Notes

Reaction equation

HRID 2372755 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[C:9]1[N:17]=[CH:16][CH:15]=[CH:14][C:10]=1[C:11]([OH:13])=[O:12]>C1(C)C(C)=CC=CC=1>[C:2]1([NH:1][C:9]2[N:17]=[CH:16][CH:15]=[CH:14][C:10]=2[C:11]([OH:13])=[O:12])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6115AnilineHCID 762582-Chloronicotinic acid

Product 1

HCID 14817992-Anilinonicotinic acid

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

50 ml of distilled aniline and 43.2 g of 2-chloronicotinic acid are mixed in 126 ml of xylene. The mixture is brought to reflux for 4 hours. It is allowed to cool and the precipitate is filtered off and washed several times with water.

Workup

  1. temperatureto reflux for 4 hours
  2. temperatureto cool
  3. filtrationthe precipitate is filtered off
  4. washwashed several times with water

Sources & evidence

ORD record
ord-534dc20d57534045ab438b70c8a0baff
Source dataset
uspto-grants-1992_03
Patent number
US05100902

Reaction notes

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