反应详情

Propionyl chloride (0.77g, 8.3 mmol) was added to cis-1-phenylmethyl-3-methoxy-4-phenylaminopiperidine (7b, 1.6g, 5.3 mmol) from Example 4 in 30ml of dichloromethane. The reaction solution was stirred at room temperature overnight and subsequently diluted with 20ml of 10% sodium hydroxide solution. The organic layer was separated and the aqueous layer was extracted with 2×50ml of dichloromethane. The combined organic layers were dried and concentrated under vacuum to yield 1.84g (99%) of crude cis-N-phenyl-N-(1-phenylmethyl-3-methoxy-4-piperidinyl) propanamide (I).

1. customThe organic layer was separated
2. extractionthe aqueous layer was extracted with 2×50ml of dichloromethane
3. customThe combined organic layers were dried
4. concentrationconcentrated under vacuum