Propionyl chloride → HCID 86744622, compound

Participants

Reaction Steps

Propionyl chloride (0.77g, 8.3 mmol) was added to cis-1-phenylmethyl-3-methoxy-4-phenylaminopiperidine (7b, 1.6g, 5.3 mmol) from Example 4 in 30ml of dichloromethane. The reaction solution was stirred at room temperature overnight and subsequently diluted with 20ml of 10% sodium hydroxide solution. The organic layer was separated and the aqueous layer was extracted with 2×50ml of dichloromethane. The combined organic layers were dried and concentrated under vacuum to yield 1.84g (99%) of crude cis-N-phenyl-N-(1-phenylmethyl-3-methoxy-4-piperidinyl) propanamide (I).

Provenance & Evidence