反应详情

温度

50 °C

A 6 N solution of aq. HCl (5 mL) was added to tert-butyl (2R)-2-hydroxy-2-pyrimidin-2-ylethyl(methyl)carbamate (1.17 g) at room temperature. After 2.5 h, reaction mixture was concentrated in vacuo using 3×10 mL portions of ethanol to assist in water removal. The oil was dissolved in ethanol, heated to ca. 50° C. and THF was added until slightly turbid at this temperature. The solution was allowed to cool to room temperature. The resulting solid was collected by filtration and washed with ethanol/THF (50/50) followed by diethyl ether to afford 0.78 g of the title compound.

1. customreaction mixture
2. concentrationwas concentrated in vacuo
3. customremoval
4. dissolutionThe oil was dissolved in ethanol
5. additionTHF was added until slightly turbid at this temperature
6. temperatureto cool to room temperature
7. filtrationThe resulting solid was collected by filtration
8. washwashed with ethanol/THF (50/50)