HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 5-Methoxy-2-thiophenecarbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5-Methoxythiophene-2-carboxylic acid | HCID 5188119 | — |
| Product | 5-Methoxy-2-thiophenecarbonyl chloride | HCID 14721834 | — |
Reaction Steps
15.0 g (94.8 mmol) 5-methoxy-2-thiophenecarboxylic acid were heated in 100 ml thionyl chloride and 1 ml abs. DMF for 30 minutes under reflux. The excess thionyl chloride was then distilled off under vacuum. The crude product (ca. 18 g brownish oil) was quickly distilled.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05100911 |
| Source dataset | uspto-grants-1992_03 |
| ORD ID | ord-1452a7b06c4c430c81613e4120d22733 |
| Source note | uspto-grants-1992_03 |