反应详情

15.0 g (94.8 mmol) 5-methoxy-2-thiophenecarboxylic acid were heated in 100 ml thionyl chloride and 1 ml abs. DMF for 30 minutes under reflux. The excess thionyl chloride was then distilled off under vacuum. The crude product (ca. 18 g brownish oil) was quickly distilled.

1. distillationThe excess thionyl chloride was then distilled off under vacuum
2. distillationThe crude product (ca. 18 g brownish oil) was quickly distilled